Karlsson Tiselius, Andreas
- Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
Sammanfattning
Binding of oxygen to iron is exploited in several biological and chemical processes. Although computational and spectroscopic results have suggested side-on binding, only end-on binding of oxygen to iron has been observed in crystal structures. We have determined structures of naphthalene dioxygenase that show a molecular oxygen species bound to the mononuclear iron in a side-on fashion. In a complex with substrate and dioxygen, the dioxygen molecule is lined up for an attack on the double bond of the aromatic substrate. The structures reported here provide the basis for a reaction mechanism and for the high stereospecificity of the reaction catalyzed by naphthalene dioxygenase.
Publicerad i
Science
2003, volym: 299, nummer: 5609, sidor: 1039-1042
Utgivare: AMER ASSOC ADVANCEMENT SCIENCE
SLU författare
Eklund, Hans
- Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
- Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Miljö- och naturvårdsvetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1126/science.1078020
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/796