Widespread episodic thiamine deficiency in Northern Hemisphere wildlife

Sammanfattning

Many wildlife populations are declining at rates higher than can be explained by known threats to biodiversity. Recently, thiamine (vitamin B-1) deficiency has emerged as a possible contributing cause. Here, thiamine status was systematically investigated in three animal classes: bivalves, ray-finned fishes, and birds. Thiamine diphosphate is required as a cofactor in at least five life-sustaining enzymes that are required for basic cellular metabolism. Analysis of different phosphorylated forms of thiamine, as well as of activities and amount of holoenzyme and apoenzyme forms of thiaminedependent enzymes, revealed episodically occurring thiamine deficiency in all three animal classes. These biochemical effects were also linked to secondary effects on growth, condition, liver size, blood chemistry and composition, histopathology, swimming behaviour and endurance, parasite infestation, and reproduction. It is unlikely that the thiamine deficiency is caused by impaired phosphorylation within the cells. Rather, the results point towards insufficient amounts of thiamine in the food. By investigating a large geographic area, by extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemical alterations to secondary effects, we demonstrate that the problem of thiamine deficiency is considerably more widespread and severe than previously reported.

Nyckelord

Thiamine; Anguilla; eel; salmon; herring; eider; Mytilus

Publicerad i

Scientific Reports
2016, volym: 6, artikelnummer: 38821
Utgivare: NATURE PUBLISHING GROUP

SLU författare

• Karlsson, Simon

  • Institutionen för akvatiska resurser (SLU Aqua), Sveriges lantbruksuniversitet
    
  • Karlstads universitet

• Strömquist, Jennie

  • Institutionen för akvatiska resurser (SLU Aqua), Sveriges lantbruksuniversitet
    

• Börjeson, Hans

  • Institutionen för akvatiska resurser (SLU Aqua), Sveriges lantbruksuniversitet
    

Associerade SLU-program

Kust och hav
Sjöar och vattendrag

Globala målen (SDG)

SDG15 Ekosystem och biologisk mångfald

UKÄ forskningsämne

Zoologi
Miljövetenskap
Biokemi och molekylärbiologi

Publikationens identifierare

• DOI: https://doi.org/10.1038/srep38821

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/80356