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Background The stress reaction induced by surgery and associated pain may be detrimental for patient recovery and should be minimized. The neuropeptide chromogranin A (CGA) has shown promise as a sensitive biomarker for stress in humans. Little is known about CGA and its derived peptides, catestatin (CST) and vasostatin (VS), in dogs undergoing surgery. The objectives of this study were to investigate and compare concentrations of CGA epitopes CST and VS, cortisol, body temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF) and visual analog scales (VAS) for stress and pain behavior in dogs before and after ovariohysterectomy. Methods Thirty healthy privately owned female dogs admitted for elective ovariohysterectomy were included. Physical examination, CMPS-SF, pain behavior VAS, and stress behavior VAS were recorded and saliva and blood samples were collected before surgery, 3h after extubation, and once at recall 7–15days after surgery. Dogs were premedicated with morphine and received carprofen as analgesia for 7days during the postoperative period. Results At 3h after extubation, CMPS-SF and pain behavior VAS scores had increased (p

Publicerad i

BMC Research Notes
2016, volym: 9, artikelnummer: 381

SLU författare

UKÄ forskningsämne

Fysiologi och anatomi
Kirurgi

Publikationens identifierare

  • DOI: https://doi.org/10.1186/s13104-016-2193-1

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/80653