Biomimetic spinning of artificial spider silk from a chimeric minispidroin

Sammanfattning

Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.

Publicerad i

Nature Chemical Biology
2017, volym: 13, nummer: 3, sidor: 262-264
Utgivare: NATURE PUBLISHING GROUP

SLU författare

• Andersson, Marlene

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Johansson, Jan

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Karolinska institutet

• Rising, Anna

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Karolinska institutet

UKÄ forskningsämne

Strukturbiologi
Biomaterialvetenskap

Publikationens identifierare

• DOI: https://doi.org/10.1038/NCHEMBIO.2269

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/80753