Rosenmai, Anna
- Danmarks Tekniske Universitet (DTU)
Sammanfattning
Migration of chemicals from packaging materials to foods may lead to human exposure. Polyfluoroalkyl substances (PFAS) can be used in technical mixtures (TMs) for use in food packaging of paper and board, and PFAS have been detected in human serum and umbilical cord blood. The specific structures of the PFAS in TMs are often unknown, but polyfluorinated alkyl phosphate esters (PAPs) have been characterized in TMs, food packaging, and in food. PAPs can be metabolized into fluorotelomer alcohols (FTOHs) and perfluoroalkyl carboxylic acids (PFCAs). Some PFAS have endocrine activities, highlighting the need to investigate these effects. Herein, we studied the endocrine activity of less characterized PFAS, including short-chain PFCAs and FTOHs, PAPs, and TMs of unknown chemical composition. Long-chain PFCAs were also included. We applied seven assays covering effects on estrogen, glucocorticoid, androgen, and peroxisome proliferator-activated receptor (PPAR) activity, as well as steroidogenesis in vitro and ex vivo. In general, PAPs, FTOHs, TMs, and long-chain PFCAs showed estrogenic activity through receptor activation and/or increasing 17 beta-estradiol levels. Furthermore, short- and long-chain PFCAs activated PPAR alpha and PPAR gamma. Collectively, this means that (i) PAPs, FTOHs, and PFCAs exhibit endocrine activity through distinct and sometimes different mechanisms, (ii) two out of three tested TMs exhibited estrogenic activity, and (iii) short-chain FTOHs showed estrogenic activity and short-chain PFCAs generally activate both PPAR alpha and PPAR gamma with similar potency and efficacy as long-chain PFCAs. In conclusion, several new and divergent toxicological targets were identified for different groups of PFAS.
Nyckelord
estrogenic activity; fluorotelomer alcohols; perfluoroalkyl carboxylic acids; peroxisome proliferator-activated receptor; polyfluorinated alkyl phosphate esters; polyfluoroalkyl substances
Publicerad i
Andrology
2016, volym: 4, nummer: 4, sidor: 662-672
Utgivare: WILEY-BLACKWELL
SLU författare
Globala målen (SDG)
SDG3 God hälsa och välbefinnande
UKÄ forskningsämne
Livsmedelsvetenskap
Farmakologi och toxikologi
Publikationens identifierare
- DOI: https://doi.org/10.1111/andr.12190
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/83226