Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor

Sammanfattning

A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

Publicerad i

Journal of Medicinal Chemistry
2006, volym: 49, nummer: 23, sidor: 6635-6637
Utgivare: AMER CHEMICAL SOC

SLU författare

• Agback, Peter

  • Karo Bio AB

UKÄ forskningsämne

Organisk kemi

Publikationens identifierare

• DOI: https://doi.org/10.1021/jm060521i

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/83871