Molecular Diversification in the Quorum-Sensing System of Vibrio cholerae: Role of Natural Selection in the Emergence of Pandemic Strains

Sammanfattning

Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.

Publicerad i

Applied and Environmental Microbiology
2009, volym: 75, nummer: 11, sidor: 3808-3812
Utgivare: AMER SOC MICROBIOLOGY

SLU författare

• Ingvarsson, Pär

  • Umeå Universitet

UKÄ forskningsämne

Mikrobiologi
Evolutionsbiologi

Publikationens identifierare

• DOI: https://doi.org/10.1128/AEM.02496-08

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/84119