JMJ14, a JmjC domain protein, is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis

Sammanfattning

JMJ14 is a histone H3 Lys4 (H3K4) trimethyl demethylase that affects mobile RNA silencing in an Arabidopsis transgene system. It also influences CHH DNA methylation, abundance of endogenous transposon transcripts, and flowering time. JMJ14 acts at a point in RNA silencing pathways that is downstream from RNA-dependent RNA polymerase 2 (RDR2) and Argonaute 4 (AGO4). Our results illustrate a link between RNA silencing and demethylation of histone H3 trimethylysine. We propose that JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing.

Nyckelord

RNA silencing; Arabidopsis; siRNAs; chromatin; histone demethylase

Publicerad i

Genes and Development
2010, volym: 24, nummer: 10, sidor: 986--991
Utgivare: Cold Spring Harbor Laboratory Press

SLU författare

• Melnyk, Charles

  • University of Cambridge

UKÄ forskningsämne

Genetik och genomik

Publikationens identifierare

• DOI: https://doi.org/10.1101/gad.579910

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/84651