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Sammanfattning

Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease is a neurological disorder linked to environmental exposure to a non-protein amino acid, beta-N-methylamino-L-alanine (BMAA). The only organisms reported to be BMAA-producing, are cyanobacteria - prokaryotic organisms. In this study, we demonstrate that diatoms - eukaryotic organisms - also produce BMAA. Ultra-high-performance liquid chromatography coupled with tandem mass spectrometry revealed the occurrence of BMAA in six investigated axenic diatom cultures. BMAA was also detected in planktonic field samples collected on the Swedish west coast that display an overrepresentation of diatoms relative to cyanobacteria. Given the ubiquity of diatoms in aquatic environments and their central role as primary producers and the main food items of zooplankton, the use of filter and suspension feeders as livestock fodder dramatically increases the risk of human exposure to BMAA-contaminated food.

Publicerad i

PLoS ONE
2014, volym: 9, nummer: 1, artikelnummer: e84578
Utgivare: PUBLIC LIBRARY SCIENCE

SLU författare

  • Lage, Sandra

    • Stockholms Universitet

UKÄ forskningsämne

Ekologi
Botanik
Analytisk kemi

Publikationens identifierare

  • DOI: https://doi.org/10.1371/journal.pone.0084578

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/87580