The controversial role of mast cells in fibrosis

Sammanfattning

Fibrosis is a medical condition characterized by an excessive deposition of extracellular matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases and can affect all organs. The excessive extracellular matrix accumulation in these conditions can often have serious consequences and in many cases be life-threatening. A typical event seen in many fibrotic conditions is a profound accumulation of mast cells (MCs), suggesting that these cells can contribute to the pathology. Indeed, there is now substantialv evidence pointing to an important role of MCs in fibrotic disease. However, investigations from various clinical settings and different animal models have arrived at partly contradictory conclusions as to how MCs affect fibrosis, with many studies suggesting a detrimental role of MCs whereas others suggest that MCs can be protective. Here, we review the current knowledge of how MCs can affect fibrosis.

Nyckelord

fibrosis; heart; kidney; liver; lung; mast cell; skin

Publicerad i

Immunological Reviews
2018, volym: 282, nummer: 1, sidor: 198-231
Utgivare: WILEY

SLU författare

• Pejler, Gunnar

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Uppsala universitet

Associerade SLU-program

Translationell och komparativ medicin

UKÄ forskningsämne

Immunologi

Publikationens identifierare

• DOI: https://doi.org/10.1111/imr.12626

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/94028