Ljung, Karin
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
Research article2017Peer reviewedOpen access
Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root
Di Mambro, Riccardo; De Ruvo, Micol; Pacifici, Elena; Salvi, Elena; Sozzani, Rosangela; Benfey, Philip N.; Busch, Wolfgang; Novak, Ondrej; Ljung, Karin; Di Paola, Luisa; Maree, Athanasius F. M.; Costantino, Paolo; Grieneisen, Veronica A.; Sabatini, Sabrina
Abstract
In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin's control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a welldefined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size.
Keywords
plant hormones; cell differentiation; root meristem; computational modeling
Published in
Proceedings of the National Academy of Sciences of the United States of America
2017, volume: 114, number: 36, pages: E7641-E7649
Publisher: NATL ACAD SCIENCES
SLU Authors
UKÄ Subject classification
Bioinformatics and Computational Biology (Methods development to be 10203)
Publication identifier
- DOI: https://doi.org/10.1073/pnas.1705833114
Permanent link to this page (URI)
https://res.slu.se/id/publ/94089