Seisenbaeva, Gulaim
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. alpha-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine alpha-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected. The alpha-Fe2O3 NPs exhibited a noticeable toxicity, with kinin/kallikrein activation, which may be associated with hypotension and long-term angiogenesis in vivo, with implications for cancer, arteriosclerosis and pulmonary disease. (c) 2017 Elsevier Inc. All rights reserved.
Nyckelord
alpha-Fe2O3 NPs; Contact/kallikrein system; Innate immunity
Publicerad i
Nanomedicine: Nanotechnology, Biology and Medicine
2018, volym: 14, nummer: 3, sidor: 735-744
Utgivare: ELSEVIER SCIENCE BV
SLU författare
Kessler, Vadim
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
Globala målen (SDG)
SDG3 God hälsa och välbefinnande
UKÄ forskningsämne
Immunologi inom det medicinska området
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.nano.2017.12.008
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/95007