Sundell-Bergman, Synnöve
- Department of Soil and Environment, Swedish University of Agricultural Sciences
Abstract
Background: Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model.Methods: Male mice were exposed to a single dose of ketamine (7.5 mg kg(-1) body weight) s.c. on postnatal day 10. One hour after ketamine exposure, mice were whole body irradiated with 50-200 mGy gamma radiation (Cs-137). Behavioural observations were performed at 2, 4 and 5 months of age. At 6 months of age, cerebral cortex and hippocampus tissue were analysed for neuroprotein levels.Results: Animals co-exposed to IR and ketamine displayed significant (P
Keywords
cognition; gamma rays; ketamine; mice; tau proteins
Published in
British Journal of Anaesthesia
2018, volume: 120, number: 3, pages: 546-554
Publisher: ELSEVIER SCI LTD
SLU Authors
UKÄ Subject classification
Radiology and Medical Imaging
Neurology
Publication identifier
- DOI: https://doi.org/10.1016/j.bja.2017.11.099
Permanent link to this page (URI)
https://res.slu.se/id/publ/96135