Sundell-Bergman, Synnöve
- Institutionen för mark och miljö, Sveriges lantbruksuniversitet
Sammanfattning
Background: Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model.Methods: Male mice were exposed to a single dose of ketamine (7.5 mg kg(-1) body weight) s.c. on postnatal day 10. One hour after ketamine exposure, mice were whole body irradiated with 50-200 mGy gamma radiation (Cs-137). Behavioural observations were performed at 2, 4 and 5 months of age. At 6 months of age, cerebral cortex and hippocampus tissue were analysed for neuroprotein levels.Results: Animals co-exposed to IR and ketamine displayed significant (P
Nyckelord
cognition; gamma rays; ketamine; mice; tau proteins
Publicerad i
British Journal of Anaesthesia
2018, volym: 120, nummer: 3, sidor: 546-554
Utgivare: ELSEVIER SCI LTD
SLU författare
UKÄ forskningsämne
Radiologi och bildbehandling
Neurologi
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.bja.2017.11.099
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/96135