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Sammanfattning

Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted H-1 NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG, higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism.

Nyckelord

metabolomics; NMR; hypocaloric diet; physical activity; metabolically healthy obesity

Publicerad i

Journal of Proteome Research
2018, volym: 17, nummer: 8, sidor: 2600-2610
Utgivare: AMER CHEMICAL SOC

SLU författare

UKÄ forskningsämne

Näringslära och dietkunskap

Publikationens identifierare

  • DOI: https://doi.org/10.1021/acs.jproteome.8b00042

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/96589