Burkina, Viktoriia
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
- Jihočeská univerzita v Českých Budějovicích
Naturally- and anthropogenically-produced cresols could pose serious risks to fish health. In this study, three piscine CYP isoforms were investigated for their abilities to interact with p-cresol. Therefore, the activity of 7-ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD), and p-nitrophenol hydroxylase (PNPH) were evaluated in the hepatic microsomes of juvenile rainbow trout. Results showed that EROD activity was inhibited in a competitive manner, BFCOD activity was inhibited in presence the highest tested p-cresol concentration and PNPH activity was not affected. These results indicate that p-cresol might affect the ability of fish to metabolize numerous aromatic hydrocarbons and dioxin compounds, which are present in the aquatic environment.
CYP1A1; CYP3A-like; CYP2E1-like; Fish; p-Cresol
Environmental toxicology and pharmacology
2018, volym: 62, sidor: 199-202
Utgivare: ELSEVIER SCIENCE BV
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Farmakologi och toxikologi
https://res.slu.se/id/publ/96651