The gut microbiome participates in transgenerational inheritance of low-temperature responses in Drosophila melanogaster

Sammanfattning

Environmental perturbations induce transcriptional changes, some of which may be inherited even in the absence of the initial stimulus. Previous studies have focused on transfers through the germline although microbiota is also passed on to the offspring. Thus, we inspected the involvement of the gut microbiome in transgenerational inheritance of environmental exposures in Drosophila melanogaster. We grew flies in the cold versus control temperatures and compared their transcriptional patterns in both conditions as well as in their offspring. F2 flies grew in control temperature, while we controlled their microbiota acquisition from either F1 sets. Transcriptional status of some genes was conserved transgenerationally, and a subset of these genes, mainly expressed in the gut, was transcriptionally dependent on the acquired microbiome.

Nyckelord

Drosophila melanogaster; environmental response; gut microbiota; host-microbiome interaction

Publicerad i

FEBS Letters
2018, volym: 592, nummer: 24, sidor: 4078-4086
Utgivare: WILEY

SLU författare

• Delhomme, Nicolas

  • Institutionen för skoglig genetik och växtfysiologi, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Mikrobiologi

Publikationens identifierare

• DOI: https://doi.org/10.1002/1873-3468.13278

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/97654