Hormetic Dose Response of NaAsO2 on Cell Proliferation of Prostate Cells in Vitro: Implications for Prostate Cancer Initiation and Therapy

Abstract

Sodium meta-arsenite (NaAsO2) has been suggested to play a role both in initiation/progression of prostate cancer and as a future antiprostate cancer drug. We have studied the effects of NaAsO2 on cell proliferation of prostate cancer and noncancer cells, breast cancer cells, and adrenocortical carcinoma cells in vitro. Further, we have investigated the effect of NaAsO2 on the androgen receptor. We report that NaAsO2 alters the cell proliferation of prostate cells, in a hormetic manner, by increasing cell proliferation at low concentrations and decreasing the cell proliferation at high concentrations. No activation of the androgen receptor was detected. We conclude that NaAsO2 is able to increase cell proliferation of prostate cells in vitro at low concentrations, while it decreases cell viability at high concentrations. This novel finding has to be further addressed if NaAsO2 should be developed into an antiprostate cancer drug.

Keywords

androgen receptor activation; cell viability; hormetic effects; prostate cancer

Published in

Dose-Response
2019, volume: 17, number: 2, article number: 1559325819843374
Publisher: SAGE PUBLICATIONS INC

SLU Authors

• Lundqvist, Johan

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Helmersson, Erik

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Oskarsson, Agneta

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

Global goals (SDG)

SDG3 Good health and well-being

UKÄ Subject classification

Pharmacology and Toxicology

Publication identifier

• DOI: https://doi.org/10.1177/1559325819843374

Permanent link to this page (URI)

https://res.slu.se/id/publ/100095