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Forskningsartikel2019Vetenskapligt granskadÖppen tillgång

Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd-0-CalB CLEA as a Biohybrid Catalyst

Gustafson, Karl P. J.; Gorbe, Tamas; de Gonzalo-Calvo, Gonzalo; Yuan, Ning; Schreiber, Cynthia L.; Shchukarev, Andrey; Tai, Cheuk-Wai; Persson, Ingmar; Zou, Xiaodong; Backvall, Jan-E.

Sammanfattning

Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.

Nyckelord

amides; biohybrid catalysts; dynamic kinetic resolution; heterogeneous catalysis; key cross-linked enzyme aggregates

Publicerad i

Chemistry - A European Journal
2019, Volym: 25, nummer: 39, sidor: 9174-9179
Utgivare: WILEY-V C H VERLAG GMBH