Research article - Peer-reviewed, 2006
Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran
Landberg R, Linko AM, Kamal-Eldin A, Vessby B, Adlercreutz H, Aman PAbstract
Alkylresorcinols (ARs) are phenolic lipids present in whole grain and bran of wheat and rye. Chemically, they comprise 1,3-dihydroxy-5-alkylbenzene homologs with odd-numbered, mainly saturated hydrocarbon side chains in the range of 17-25 carbon atoms. ARs are evaluated both for physiological effects and for their potential use as biomarkers of whole-grain wheat and rye intake. In this study, plasma kinetics and relative bioavailability of ARs in humans were investigated after a single intake of rye bran 120 g (190 mg ARs). The shapes of plasma concentration time curves were similar in the subjects (n = 6) with 2 peaks at similar to 2.8 and 6.5 h and maximum concentrations (mean +/- SEM) of 1253 +/- 125 and 3365 +/- 309 nmol/L, respectively. The relative bioavailability of different homologs increased with increasing length of the AR side chain (r = 0.97, P < 0.001), indicating differences in metabolism. The apparent half-lives were rather short, similar to 5 h for all homologs, which suggests that the AR concentration in plasma could be used as a short- to medium-term biomarker of regular intake of whole-grain wheat and ryePublished in
Journal of Nutrition2006, volume: 136, number: 11, pages: 2760-2765
Publisher: AMER SOCIETY NUTRITIONAL SCIENCE
Authors' information
Landberg, Rikard
Swedish University of Agricultural Sciences, Department of Food Science
Kamal-Eldin, Afaf
Swedish University of Agricultural Sciences, Department of Food Science
Swedish University of Agricultural Sciences, Department of Food Science
Linko, A-M
Vessby, B
Adlercreutz, H
UKÄ Subject classification
Food Science
URI (permanent link to this page)
https://res.slu.se/id/publ/10244