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Forskningsartikel2020Vetenskapligt granskadÖppen tillgång

The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites

Senanayake, Kanchana S.; Soderberg, Jonas; Polajev, Aleksei; Malmberg, Maja; Karunanayake, Eric H.; Tennekoon, Kamani H.; Samarakoon, Sameera R.; Bongcam-Rudloff, Erik; Niazi, Adnan

Sammanfattning

Here we present the draft genome sequence of Setaria digitata, a parasitic nematode affecting cattle. Due to its similarity to Wuchereria bancrofti, the parasitic nematode that causes lymphatic filariasis in humans, S. digitata has been used as a model organism at the genomic level to find drug targets which can be used for the development of novel drugs and/or vaccines for human filariasis. Setaria digitata causes cerebrospinal nematodiasis in goats, sheep, and horses posing a serious threat to livestock in developing countries. The genome sequence of S. digitata will assist in finding candidate genes to use as drug targets in both S. digitata and W. bancrofti. The assembled draft genome is similar to 90 Mb long and contains 8,974 genomicscaffolds with a G+C content of 31.73%.

Nyckelord

Setaria digitata; cerebrospinal nematodiasis; setariosis; filariasis; helminth; genome; cattle parasite

Publicerad i

Genome Biology and Evolution
2020, Volym: 12, nummer: 2, sidor: 3971-3976 Utgivare: OXFORD UNIV PRESS