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Research article2020Peer reviewed

Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

Winkler, Janine; Xu, Ya; Gong, Yun Yun; Lindahl, Johanna; Kersten, Susanne; Daenicke, Sven; Routledge, Michael N.

Abstract

The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.

Keywords

Aflatoxin-albumin adduct; Biomarker; Aflatoxin M-1; ELISA; Dairy cow

Published in

Mycotoxin Research
2020, Volume: 36, number: 2, pages: 207-211 Publisher: SPRINGER HEIDELBERG

      UKÄ Subject classification

      Clinical Science
      Animal and Dairy Science

      Publication identifier

      DOI: https://doi.org/10.1007/s12550-019-00383-7

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/105610