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Research article - Peer-reviewed, 1992

Bovine virus diarrhoea virus induces in vitro a proliferative response of peripheral blood mononuclear cells from cattle immunized by infection

Larsson, Bengt; Fossum, Caroline


The ability of bovine peripheral blood mononuclear cells (PBMC) to mount a proliferative response to bovine virus diarrhoea virus (BVDV) in vitro was examined. After culturing PBMC in the presence of a non-cytopathic strain of BVDV for 6 days, the magnitude of PBMC proliferation was measured as incorporation of radiolabelled thymidine, present during the last 18 h.Live, but not heat-inactivated, BVDV evoked a proliferative response of PBMC obtained from cattle seropositive to the virus. However, PBMC from seronegative or persistently BVDV-infected animals were not stimulated by BVDV. The presence of live BVDV did not alter the proliferative response of PBMC to stimulation with concanavalin A.

Published in

Veterinary Microbiology
1992, Volume: 31, number: 4, pages: 317-325

      SLU Authors

    • Fossum, Caroline

      • Department of Veterinary Microbiology, Swedish University of Agricultural Sciences

    UKÄ Subject classification

    Clinical Science

    Publication identifier


    Permanent link to this page (URI)