Ekesten, Björn
- Institutionen för kirurgi och medicin, stordjur, Sveriges lantbruksuniversitet
Forskningsartikel2001Vetenskapligt granskad
Ekesten, B; Gouras, P; Salchow, DJ
Ultra-violet (UV) and middle wavelength sensitive (M) cone responses were identified in the ERG of normal and Rpe65 -/- mice using chromatic flashes and selective chromatic adaptation. In normal mice, the UV-cone response was as large as, or larger, in the presence of a bright yellow adapting light than it is in the presence of a dim white light. The M-cone response became undetectable in the presence of the yellow adapting light. Yellow adapting light initially reduced the UV response, but it recovered in 8-10 min. The M-cone response did not recover. UV-cone responses were undetectable in Rpe65 -/- mice. The M-cone response of young Rpe65 -/- mice was almost as large as in normal mice. A yellow adapting light only diminished this M-cone response. With age, the M-cone response further decreased in Rpe -/- mice. We show a pronounced loss of UV-cone function in Rpe65 -/- mice, which may be related to a defect UV-cones share with rods. The M-cone function is also affected already in young Rpe65 -/- mice. The transient effect of a yellow adapting light on the UV-cone response of normal mice is suggested to be neural, because it disappears during maintained light adaptation. (C) 2001 Elsevier Science Ltd. All rights reserved.
mouse; Rpe65; electroretinogram; cones; ultra-violet
Vision Research
2001, Volym: 41, nummer: 19, sidor: 2425-2433 Utgivare: PERGAMON-ELSEVIER SCIENCE LTD
Oftalmologi
DOI: https://doi.org/10.1016/S0042-6989(01)00140-7
https://res.slu.se/id/publ/107312