Skip to main content
SLU:s publikationsdatabas (SLUpub)

Forskningsartikel2021Vetenskapligt granskadÖppen tillgång

Impact of a Fermented High-Fiber Rye Diet on Helicobacter pylori and Cardio-Metabolic Risk Factors: A Randomized Controlled Trial Among Helicobacter pylori-Positive Chinese Adults

Xue, Kun; Liu, Yuwei; Iversen, Kia Nohr; Mazidi, Mohsen; Qu, Zheng; Dong, Chenglin; Jin, Tayi; Hallmans, Goran; Aman, Per; Johansson, Anders; He, Gengsheng; Landberg, Rikard

Sammanfattning

Background: High dietary fiber intake has been associated with reduced risk of Helicobacter pylori infection and co-morbidities such as gastric cancer but also with reduced risk of cardiovascular disease. It has been suggested that fermented rye could affect Helicobacter pylori bacterial load and that high- fiber rye may be superior to wheat for improvement of several cardiometabolic risk factors, but few long-term interventions with high fiber rye foods have been conducted.Objective: To examine the effect of high-fiber wholegrain rye foods with added fermented rye bran vs. refined wheat on Helicobacter pylori infection and cardiometabolic risk markers in a Chinese population with a low habitual consumption of high fiber cereal foods.Design: A parallel dietary intervention was set up and 182 normal- or overweight men and women were randomized to consume wholegrain rye products containing fermented rye bran (FRB) or refined wheat (RW) for 12 weeks. Anthropometric measurements, fasting blood sample collection and C-13-urea breath test (C-13-UBT) were performed at baseline and after 6 and 12 weeks of intervention as well as 12 weeks after the end of the intervention.Results: No difference between diets on Helicobacter pylori bacterial load measured by C-13-UBT breath test or in virulence factors of Helicobacter pylori in blood samples were found. Low density lipoprotein cholesterol (LDL-C) and high sensitivity C-reactive protein (hs-CRP) were significantly lower in the FRB group, compared to the RW group after 12 weeks of intervention. The intervention diets did not affect markers of glucose metabolism or insulin sensitivity.Conclusions: While the results of the present study did not support any effect of FRB on Helicobacter pylori bacterial load, beneficial effects on LDL-C and hs-CRP were clearly shown. This suggest that consumption of high fiber rye foods instead of refined wheat could be one strategy for primary prevention of cardiovascular disease.

Nyckelord

wholegrain; rye; cardiovascular disease; Helicobacter pylori; inflammation; LDL cholesterol; C-reactive protein; cereal fiber

Publicerad i

Frontiers in Nutrition
2021, Volym: 7, artikelnummer: 608623Utgivare: FRONTIERS MEDIA SA

    Globala målen

    SDG3 God hälsa och välbefinnande

    UKÄ forskningsämne

    Näringslära

    Publikationens identifierare

    DOI: https://doi.org/10.3389/fnut.2020.608623

    Permanent länk till denna sida (URI)

    https://res.slu.se/id/publ/110781