Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection

Sammanfattning

Gastrointestinal nematodes (GIN) are an important constraint in small ruminant production. Genetic selection for resistant animals is a potential sustainable control strategy. Advances in molecular genetics have led to the identification of several molecular genetic markers associated with genes affecting economic relevant traits. In this study, the variants in the genome of Creole goats resistant or susceptible to GIN were discovered from RNA-sequencing. We identified SNPs, insertions and deletions that distinguish the two genotypes, resistant and susceptible and we characterized these variants through functional analysis. The T cell receptor signalling pathway was one of the top significant pathways that distinguish the resistant from the susceptible genotype with 78% of the genes involved in this pathway showing genomic variants. These genomic variants are expected to provide useful resources especially for molecular breeding for GIN resistance in goats.

Publicerad i

PLoS ONE
2021, Volym: 16, nummer: 3, artikelnummer: e0248405
Utgivare: PUBLIC LIBRARY SCIENCE

SLU författare

• Aboshady, Hadeer

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • AgroParisTech
  • Cairo University
  • Institut national de la recherche agronomique (INRA)

• Johansson, Anna Maria

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Jonas, Elisabeth

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Klinisk vetenskap


Publikationens identifierare

DOI: https://doi.org/10.1371/journal.pone.0248405

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/111491