Eriksson, Staffan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2009Peer reviewedOpen access
Guan, Hong; Sun, Yanhua; Zan, Qin; Xu, Meiquan; Li, Yuan; Zhou, Ji; He, Ellen; Eriksson, Staffan; Wen, Wen; Skog, Sven
Thymidine kinase 1 (TK1) is an enzyme involved in the synthesis of DNA precursors. In studies using immunohistochemistry, it was reported to be a more useful proliferation marker than Ki-67 and PCNA in breast, lung and colorectal carcinoma. In this study, we extend the work of prior breast carcinoma studies by investigating the expression of TK1 in 132 patients with usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). TK1 and Ki-67 expression were determined with monoclonal antibodies using the SP technique. The expression of TK1 was found to be significantly increased in the breast ductal carcinomas in the following manner: UDH
thymidine kinase 1; Ki-67; ductal breast cancer; usual ductal hyperplasia; atypical ductal hyperplasia; ductal carcinoma in situ; invasive ductal carcinoma; immunohistochemistry
Molecular Medicine Reports
2009, Volume: 2, number: 6, pages: 923-929
Publisher: SPANDIDOS PUBL LTD
Medicinal Chemistry
DOI: https://doi.org/10.3892/mmr_00000193
https://res.slu.se/id/publ/118205