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Forskningsartikel2023Vetenskapligt granskadÖppen tillgång

On the reactivity of 2-methylene-3-quinuclidinone in water

Ringom, Rune; Blizzard, Tim; Sandström, Corine; Svensson, Per H.; Hagberg, Lars

Sammanfattning

The biologically active Michael acceptor 2-methylene-3-quinuclidinone (MQ) has a unique chemical reactivity and forms several products upon dissolution in water. With the use of X-ray, NMR and LCMS data the structures of two previously incorrectly characterised compounds are rectified. A complex equilibrium in water, containing novel dimeric species of MQ, and its dependence on temperature, pH and concentration is presented.

Publicerad i

Heterocycles
2023, Volym: 106, nummer: 2, sidor: 271-276