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Forskningsartikel2024Vetenskapligt granskadÖppen tillgång

Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater

Bade, Richard; van Herwerden, Denice; Rousis, Nikolaos; Adhikari, Sangeet; Allen, Darren; Baduel, Christine; Bijlsma, Lubertus; Boogaerts, Tim; Burgard, Dan; Chappell, Andrew; Driver, Erin M.; Sodre, Fernando Fabriz; Fatta-Kassinos, Despo; Gracia-Lor, Emma; Gracia-Marin, Elisa; Halden, Rolf U.; Heath, Ester; Jaunay, Emma; Krotulski, Alex; Lai, Foon Yin;
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Sammanfattning

The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In this work a comprehensive suspect screening workflow following liquid chromatography - high resolution mass spectrometry analysis was established utilising the open -source InSpectra data processing platform and the HighResNPS library. In total, 278 urban influent wastewater samples from 47 sites in 16 countries were collected to investigate the presence of NPS and other drugs of abuse. A total of 50 compounds were detected in samples from at least one site. Most compounds found were prescription drugs such as gabapentin (detection frequency 79%), codeine (40%) and pregabalin (15%). However, cocaine was the most found illicit drug (83%), in all countries where samples were collected apart from the Republic of Korea and China. Eight NPS were also identified with this protocol: 3-methylmethcathinone 11%), eutylone (6%), etizolam (2%), 3-chloromethcathinone (4%), mitragynine (6%), phenibut (2%), 25I-NBOH (2%) and trimethoxyamphetamine (2%). The latter three have not previously been reported in municipal wastewater samples. The workflow employed allowed the prioritisation of features to be further investigated, reducing processing time and gaining in confidence in their identification.

Nyckelord

Suspect screening; High-resolution mass spectrometry; Illicit drugs; Wastewater-based epidemiology; New Psychoactive Substances

Publicerad i

Journal of Hazardous Materials
2024, Volym: 469, artikelnummer: 133955
Utgivare: ELSEVIER

    UKÄ forskningsämne

    Miljövetenskap
    Farmakologi och toxikologi
    Analytisk kemi

    Publikationens identifierare

    DOI: https://doi.org/10.1016/j.jhazmat.2024.133955

    Permanent länk till denna sida (URI)

    https://res.slu.se/id/publ/129666