Karlström, Åsa
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi, the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth (p = 0.02) and nasal discharge (p = 0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group (p = 0.01). The antigens used were EAG (alpha 2-macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and ScIC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant. (C) 2007 Elsevier Ltd. All rights reserved.
Nyckelord
Streptococcus equi; vaccination; horses; surface proteins
Publicerad i
Vaccine
2007, volym: 25, nummer: 18, sidor: 3629-3635
Utgivare: ELSEVIER SCI LTD
SLU författare
Lannergård, Jonas
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
Guss, Bengt
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
- Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Veterinärmedicin
Husdjursvetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.vaccine.2007.01.060
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/15347