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2003Öppen tillgång

Neural stability and flexibility: A computational approach

Lijenstrom, H

Sammanfattning

This paper addresses the issue of stability and flexibility of neural systems, and how a balance can be achieved Assuming a close correspondence with cognitive and mental processes, we use a cortical neural network model to investigate how regulation of the neurodynamics can result in an efficient information processing, in terms of learning and associative memory. In particular, we use this model to investigate relations between structure, dynamics, and function of a neural system, and how the stability-flexibility dilemma may be solved by proper regulation. We focus on the complex neurodynamics and its modulation, and how this is related to the neural circuitry, where synaptic modification and network pruning are considered. Finally, we discuss the relevance of these results to clinical and experimental neuroscience and speculate on a link between neural instability and mental disorders

Nyckelord

neurodynamics; neuromodulation; pruning; cognition; disorder; computational model

Publicerad i

Neuropsychopharmacology
2003, Volym: 28, sidor: S64-S73
Utgivare: NATURE PUBLISHING GROUP

    UKÄ forskningsämne

    Livsmedelsvetenskap

    Publikationens identifierare

    DOI: https://doi.org/10.1038/sj.npp.1300137

    Permanent länk till denna sida (URI)

    https://res.slu.se/id/publ/1962