Skip to main content
SLU publication database (SLUpub)

Research article2008Peer reviewed

Synthesis and biological evaluation of inhibitors of thymidine monophosphate kinase from Bacillus anthracis

Byun, Youngjoo; Vogel, Susan R.; Phipps, Andrew J.; Camrot, Cecilia; Eriksson, Staffan; Tiwari, Rohit; Tjarks, Werner

Abstract

Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-positive bacterium that causes anthrax. These thymidine analogues were substituted at the 5'-postion with sulfonamide-, amide-, (thio)urea-, or triazole groups, which served as lipophilic surrogates for phosphate. Three of the tested compounds produced inhibition of B. anthracis Sterne growth and/or thymidine monophosphate activity. Additional studies will be necessary to elucidate the potential of this type of B. anthracis thymidine monophosphate inhibitors as novel antibiotics in the treatment Of anthrax.

Keywords

bacillus anthracis thymidine monophosphate kinase (BaTMPK); 5'-modified; thymidine-based BaTMPK kinase inhibitors

Published in

Nucleosides, Nucleotides and Nucleic Acids
2008, Volume: 27, number: 3, pages: 244-260
Publisher: TAYLOR & FRANCIS INC

      SLU Authors

      • Sustainable Development Goals

      SDG3 Ensure healthy lives and promote well-being for all at all ages

      UKÄ Subject classification

      Veterinary Science
      Animal and Dairy Science

      Publication identifier

      DOI: https://doi.org/10.1080/15257770701845238

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/20801