Research article - Peer-reviewed, 2004
Cereal alkylresorcinols elevate gamma-tocopherol levels in rats and inhibit gamma-tocopherol metabolism in vitro
Ross AB, Chen Y, Frank J, Swanson JE, Parker RS, Kozubek A, Lundh T, Vessby B, Aman P, Kamal-Eldin AAbstract
Alkylresorcinols (AR) are a class of amphiphilic phenolic lipids present in high amounts in wheat and rye bran. They have been reported to be both growth retarding and innocuous when fed to rats, and to have a broad range of bioactivities in vitro, suggested to be related to their ability to bind to proteins and modify membranes. This study was designed to test the effects of AR (purified from rye bran) on growth, tocopherol levels, and cholesterol levels in rats. Rats were fed 1 of 4 different levels of AR for 4 wk: 0 (control), 1, 2, and 4 g/kg diet. AR did not affect final body, liver, or lung weights. The AR diets increased the levels of gamma-tocopherol in liver and lungs (P < 0.05). To investigate whether AR could have increased gamma-tocopherol levels via inhibition of tocopherol-omega-hydroxylase, HepG2 cells were incubated with AR and the metabolism of gamma-tocopherol measured. AR significantly inhibited the conversion of gamma-tocopherol to its water-soluble hydroxychroman metabolite in vitro, indicating that AR may increase gamma-tocopherol levels via inhibition of tocopherol metabolism in vivo. The 4 g AR/kg diet decreased liver cholesterol (P < 0.001), but did not affect plasma lipids. AR were detected in the perirenal adipose tissue samples of rats fed AR, indicating that they can accumulate in the fatty tissues of rats. High levels of dietary AR moderately affect gamma-tocopherol, possibly via inhibition of tocopherol metabolism, and decrease liver cholesterol in ratsPublished in
Journal of Nutrition2004, volume: 134, number: 3, pages: 506-510
Publisher: AMER INST NUTRITION
Authors' information
Alastair, Ross
Swedish University of Agricultural Sciences, Department of Food Science
Swedish University of Agricultural Sciences, Department of Animal Nutrition and Management
Swedish University of Agricultural Sciences, Department of Food Science
Kamal-Eldin, Afaf
Swedish University of Agricultural Sciences, Department of Food Science
Kozubek, Arkadiusz
Frank, Jan
Swedish University of Agricultural Sciences, Department of Food Science
Parker, Robert S
Vessby, Bengt
Swanson, Joy E
Chen, Yan
Swedish University of Agricultural Sciences, Department of Food Science
UKÄ Subject classification
Food Science
URI (permanent link to this page)
https://res.slu.se/id/publ/2299