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Review article2009Peer reviewed

Novel insights into the biological function of mast cell carboxypeptidase A

Pejler, Gunnar; Knight, Stefan D.; Henningsson, Frida; Wernersson, Sara


When mast cells are activated they can respond by releasing their secretory granule compounds, including mast cell-specific proteases of chymase, tryptase and carboxypeptidase A (MC-CPA) type. MC-CPA is a dominant protein component of the mast cell granule and the MC-CPAgene is extremely highly expressed. Despite this, relatively little has been known of its biological function. However, the recent generation of mouse strains lacking MC-CPA has opened up new possibilities for investigations related to this protease. This recent development has revealed a role for MC-CPA in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venom toxins. Here, we summarize the current knowledge of MC-CPA.

Published in

Trends in Immunology
2009, Volume: 30, number: 8, pages: 401-408

      SLU Authors

      • Knight, Stefan David

        • Department of Molecular Biology, Swedish University of Agricultural Sciences
      • UKÄ Subject classification

        Animal and Dairy Science
        Veterinary Science

        Publication identifier


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