Skip to main content
SLU:s publikationsdatabas (SLUpub)

2004

Long-term modulation by postnatal oxytocin of the alpha(2)-adrenoceptor agonist binding sites in central autonomic regions and the role of prenatal stress

Diaz-Cabiale Z, Olausson H, Sohlstrom A, Agnati LF, Narvaez JA, Uvnas-Moberg K, Fuxe K

Sammanfattning

The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus and the amygdala, as evaluated by quantitative receptor autoradiography. Maternal food restriction alone increased the affinity of the alpha(2)-agonist [H-3]UK14.304 binding sites exclusively in the NTS. In offspring from ad libitum fed dams, oxytocin treatment significantly increased the density of alpha(2)-agonist binding sites in the NTS and in the hypothalamus. The K-d value of the alpha(2)-agonist binding sites in the hypothalamus of these rats, but not in the other regions studied, was also significantly increased. In offspring from food-restricted dams, oxytocin treatment produced a significant increase of the B-max values in the hypothalamus and the amygdala and the K-d value of the alpha(2)-agonist binding sites in the NTS of these rats also was selectively and significantly increased. These results suggest that a postnatal, oxytocin-induced increase of regional alpha(2)-adrenoceptor function can be seen in adulthood by a persistent, regionally selective increase in the density of central alpha(2)-adrenoceptor agonist binding sites, in the absence of an affinity change in the NTS. Such a regional increase of alpha(2)-adrenoceptor signalling in adulthood may contribute to the anti-stress action of postnatal oxytocin. By contrast, after prenatal stress, the potential increase in alpha(2)-adrenoceptor signalling takes place via selective increases of density with no changes of affinity of the alpha(2)-agonist binding sites in the hypothalamus and the amygdala

Publicerad i

Journal of Neuroendocrinology
2004, Volym: 16, nummer: 3, sidor: 183-190
Utgivare: BLACKWELL PUBLISHING LTD