Increased spontaneous motor activity in offspring after maternal cadmium exposure during lactation

Sammanfattning

Lactating rats were exposed to 0, 5 or 25 ppm cadmium as cadmium chloride in the drinking water. A battery of neurobehavioural tests was applied to the male offspring after weaning at 5 weeks until 4 months of age. The mean cadmium levels in exposed pup kidneys ranged from 0.006 to 0.030 mg/kg wet weight at weaning, with the corresponding maternal kidney cadmium levels ranging from 4 to 13 mg/kg wet weight. Significantly increased activity during the initial 20 min of the spontaneous motor activity test was observed in the highest-dose group compared to the control group. The activity outcome was significantly positively correlated with cadmium levels in the pup kidneys. No cadmium-related changes in performance were observed in the Morris water maze, the E-shaped maze or the elevated plus-maze. The results indicate that neurobehavioural effects during development may be a more sensitive parameter for Cd toxicity than renal dysfunction. (C) 2004 Elsevier B.V. All rights reserved

Nyckelord

cadmium; lactation

Publicerad i

Environmental toxicology and pharmacology
2004, Volym: 17, nummer: 1, sidor: 35-43
Utgivare: ELSEVIER SCIENCE BV

SLU författare

• Oskarsson, Agneta

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Livsmedelsvetenskap
Husdjursvetenskap
Veterinärmedicin


Publikationens identifierare

DOI: https://doi.org/10.1016/j.etap.2004.02.001

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/4031