Abstract

Alkylresorcinols (AR) have been suggested as specific dietary biomarkers of whole-grain wheat and rye intake. AR are metabolised to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have longer apparent half-lives and were recently proposed to better reflect long-term whole-grain consumption than the intact AR. The objective of this study was to analyse the reliability-expressed by the intraclass correlation coefficient (ICC)-of AR metabolite concentrations among 100 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study who provided two fasting plasma samples 4 months apart. DHBA and DHPPA concentrations were not significantly different between the first and second measurement over the 4-month period (P > 0.05). The ICC was 0.32 (95% confidence interval (CI) = 0.13-0.49) for DHBA and 0.37 (95%CI = 0.19-0.53) for DHPPA. These results suggest that AR metabolites cannot be considered to be better biomarkers of whole-grain wheat and rye intake than the intact AR in fasting plasma (ICC = 0.42).

Keywords

alkylresorcinols; DHBA; DHPPA; biomarker; reliability; whole-grain

Published in

European Journal of Clinical Nutrition
2012, Volume: 66, number: 8, pages: 968-970
Publisher: NATURE PUBLISHING GROUP

SLU Authors

• Landberg, Rikard

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

• Åman, Per

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

Sustainable Development Goals

SDG3 Ensure healthy lives and promote well-being for all at all ages


UKÄ Subject classification

Nutrition and Dietetics


Publication identifier

DOI: https://doi.org/10.1038/ejcn.2012.66

Permanent link to this page (URI)

https://res.slu.se/id/publ/41523