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Research article - Peer-reviewed, 2012

Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner

Pejler, Gunnar; Rönnberg, Elin; Calounova, G

Abstract

Here we show that mast cells contain dopamine and that mast cell activation causes dopamine depletion, indicating its presence within secretory granules. Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin. Moreover, the expression of tyrosine hydroxylase, the key enzyme in dopamine biosynthesis, was induced during mast cell maturation; histidine decarboxylase and tryptophan hydroxylase 1 were also induced. Mast cell activation caused a robust induction of histidine decarboxylase, but no stimulation of tyrosine hydroxylase or tryptophan hydroxylase 1 expression. The present study points toward a possible role of dopamine in mast cell function.

Keywords

dopamine; histidine decarboxylase; mast cells; serglycin; tryptophan hydroxylase; tyrosine hydroxylase

Published in

Biological Chemistry
2012, Volume: 393, number: 1-2, pages: 107-112
Publisher: WALTER DE GRUYTER & CO

      SLU Authors

    • UKÄ Subject classification

      Immunology
      Biochemistry and Molecular Biology

      Publication identifier

      DOI: https://doi.org/10.1515/BC-2011-220

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/42323