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Forskningsartikel - Refereegranskat, 2012

Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

Zois, Nora; Moesgaard, Sophia; Kjelgaard-Hansen, M; Rasmussen, Caroline; Falk, Torkel; Fossing, Christine; Häggström, Jens; Pedersen, HD; Olsen, LH


CHF dogs had significantly higher MCP-1 concentrations than dogs with no or minimal MR. Among the CKCS, IL-2 and IL-7 decreased with increasing left atrial size and IL-7 also decreased with increasing MR. IL-8 decreased with increasing left ventricular end-systolic internal dimensions. MCP-1 was increased in CHF dogs compared to healthy control dogs and IL-2. IL-7 and IL-8 decreased with increasing indices of disease severity. The results suggest a role for these cytokines in canine MMVD and CHF. (C) 2011 Elsevier Ltd. All rights reserved.


Myxomatous mitral valve disease; Canine; Cytokines; Interleukins; Monocyte chemoattractant protein-1

Publicerad i

Veterinary Journal
2012, Volym: 192, nummer: 1, sidor: 106-111

    UKÄ forskningsämne

    Animal and Dairy Science
    Cardiac and Cardiovascular Systems
    Veterinary Science

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