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A fibrinogen-binding protein of Staphylococcus lugdunensis

Nilsson M, Bjerketorp J, Guss B, Frykberg L


A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows, 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved


Staphylococcus lugdunensis; fibrinogen-binding; Sdr-family; LPXTG; clumping facto; phage dispaly

Publicerad i

FEMS Microbiology Letters
2004, Volym: 241, nummer: 1, sidor: 87-93