- Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences
Falk, Torkel; Jonsson, Lennart; Olsen, Lisbeth H.; Tarnow, Inge; Pedersen, Henrik D.
Arterial narrowing significantly correlated with fibrosis (P < 0.0001) and with fractional shortening, an indicator of systolic function (P = 0.002). The grade of fibrosis was associated with shorter survival time (P = 0.002), and the papillary muscle fibrosis score tended to correlate with proximal isovelocity surface area radius (P = 0.03). Data from this study lend support to the hypothesis that naturally occurring canine CHF is affected by several factors such as MMVD, myocardial atrophy and fibrosis, and by arteriosclerosis. Further, more extensive research will be required to establish cause-effect relationships between these cardiac lesions and the pathophysiology of CHF in dogs. (C) 2010 Published by Elsevier Ltd.
Arteriosclerosis; Myxomatous mitral valve degeneration; Canine chronic congestive heart failure; Cardiac pathology; Biomarkers
2010, Volume: 185, number: 1, pages: 68-74
Publisher: ELSEVIER SCI LTD