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Research article2009Peer reviewed

Studies on the interactions between glycosylated beta(3)-peptides and the lectin Vicia villosa by saturation transfer difference NMR spectroscopy

Kaszowska, Marta; Norgren, Anna S; Arvidson, Per I; Sandström, Corine


Saturation transfer difference (STD) NMR spectroscopy was used to study the interaction of the lectin Vicia villosa (VVLB4) with alpha-D-GalNAc glycosylated beta(3)-peptides. The data were compared to those obtained with the monosaccharides D-Gal, D-GalNAc, and D-Glc as well as with those obtained with the Tn antigen alpha-glycopeptide (D-GalNAc-alpha-O-Ser/Thr), molecule naturally recognized by V. villosa. Evidence that the lectin also recognizes glycosylated beta(3)-peptides and has close contact with both the sugar and amino acid moieties was obtained. (C) 2009 Elsevier Ltd. All rights reserved.


STD NMR; Glycosylated beta(3)-peptides; Tn antigen; Lectin Vicia villosa (isolectin B-4)

Published in

Carbohydrate Research
2009, Volume: 344, number: 18, pages: 2577-2580

    UKÄ Subject classification

    Biochemistry and Molecular Biology
    Organic Chemistry

    Publication identifier


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