C1q Inhibits Immune Complex-Induced Interferon-alpha Production in Plasmacytoid Dendritic Cells A Novel Link Between C1q Deficiency and Systemic Lupus Erythematosus Pathogenesis

Lood, C; Gullstrand, Birgitta; Truedsson, L; Olin, AI; Alm, Gunnar; Rönnblom, L; Sturfelt, G; Eloranta, ML; Bengtsson, AA

doi:10.1002/art.24852

Research article2009Peer reviewed

C1q Inhibits Immune Complex-Induced Interferon-alpha Production in Plasmacytoid Dendritic Cells A Novel Link Between C1q Deficiency and Systemic Lupus Erythematosus Pathogenesis

Lood, C; Gullstrand, Birgitta; Truedsson, L; Olin, AI; Alm, Gunnar; Rönnblom, L; Sturfelt, G; Eloranta, ML; Bengtsson, AA

Abstract

Conclusion. Our findings contribute to the understanding of why C1q deficiency is such a strong risk factor for SLE and suggest an explanation for the up-regulation of the type I IFN system seen in SLE patients.

Published in

Arthritis and Rheumatism
2009, Volume: 60, number: 10, pages: 3081-3090
Publisher: WILEY-LISS

SLU Authors

Alm, Gunnar
- Department of Animal Biosciences, Swedish University of Agricultural Sciences

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

Publication identifier

DOI: https://doi.org/10.1002/art.24852

Permanent link to this page (URI)

https://res.slu.se/id/publ/49296