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Research article - Peer-reviewed, 2009

C1q Inhibits Immune Complex-Induced Interferon-alpha Production in Plasmacytoid Dendritic Cells A Novel Link Between C1q Deficiency and Systemic Lupus Erythematosus Pathogenesis

Lood, C; Gullstrand, Birgitta; Truedsson, L; Olin, AI; Alm, Gunnar; Rönnblom, L; Sturfelt, G; Eloranta, ML; Bengtsson, AA


Conclusion. Our findings contribute to the understanding of why C1q deficiency is such a strong risk factor for SLE and suggest an explanation for the up-regulation of the type I IFN system seen in SLE patients.

Published in

Arthritis and Rheumatism
2009, volume: 60, number: 10, pages: 3081-3090
Publisher: WILEY-LISS

Authors' information

Lood, C
Gullstrand, Birgitta
Truedsson, L
Olin, AI
Alm, Gunnar
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Rönnblom, L
Sturfelt, G
Eloranta, ML
Bengtsson, AA

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

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