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Abstract

Alkylresorcinols (AR), phenolic lipids exclusively present in the outer parts of wheat and rye grains, have been proposed as concentration biomarkers of whole-grain wheat and rye intake. A key feature of a good biomarker is high reproducibility, which indicates how accurately a single sample reflects the true mean biomarker concentration caused by a certain intake. In this study, the short- to medium-term reproducibility of plasma AIR was determined using samples from a crossover intervention study, where men with prostate cancer (n = 17) were fed rye whole-grain/bran or refined wheat products for 6-wk periods. AIR homologs C17:0 and C21:0 differed between the treatments (P < 0.001). The reproducibility determined by the intraclass correlation coefficient (ICC) was high (intervention period 1: ICC = 0.90 [95% CI = 0.82-0.98], intervention period 2: ICC = 0.88 [95% CI = 0.78-0.98]). The results show that a single fasting plasma sample could be used to estimate the mean plasma AIR concentration during a 6-wk intervention period with constant intake at a precision of +/- 20% (80% CI). This suggests that the plasma AR concentration can be used as a reliable short- to medium-term biomarker for whole-grain wheat and rye under intervention conditions where intake is kept constant. J. Nutr. 139: 975-980, 2009.

Published in

Journal of Nutrition
2009, volume: 139, number: 5, pages: 975-980
Publisher: AMER SOC NUTRITIONAL SCIENCE

SLU Authors

Global goals (SDG)

SDG3 Good health and well-being

UKÄ Subject classification

Food Science

Publication identifier

  • DOI: https://doi.org/10.3945/jn.108.099952

Permanent link to this page (URI)

https://res.slu.se/id/publ/49995