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Research article - Peer-reviewed, 2013

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Smolders, Lucas A.; Meij, Björn P.; Onis, David; Riemers, Frank M.; Bergknut, Niklas; Wubbolts, Rickard; Grinwis, Guy C.M.; Houweling, Martin; Groot Koerkamp, Marian J.A.; van Lenen, Dik; Holstege, Frank; Hazewinkel, H.A.W.; Creemers, LB; Penning, LC; Tryfonidou, Marianna A.


Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.

Published in

Arthritis Research and Therapy
2013, volume: 15, number: 1

Authors' information

Smolders, Lucas A.
Utrecht University
Meij, Björn P.
Utrecht University
Onis, David
Utrecht University
Riemers, Frank M.
Utrecht University
Bergknut, Niklas
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Wubbolts, Rickard
Utrecht University
Grinwis, Guy C.M.
Utrecht University
Houweling, Martin
Utrecht University
Groot Koerkamp, Marian J.A.
University Medical Center Utrecht
van Lenen, Dik
University Medical Center Utrecht
Holstege, Frank
Hazewinkel, H.A.W.
Creemers, LB
Penning, LC
Tryfonidou, Marianna A.
Utrecht University

UKÄ Subject classification

Other Veterinary Science

Publication Identifiers


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