Liu, Haoyu
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
- Uppsala University
Review article2014Peer reviewedOpen access
Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota
Liu, Haoyu; Dicksved, Johan; Lundh, Torbjörn; Lindberg, Jan Erik
Abstract
Trillions of microorganisms that inhabit the intestinal tract form a diverse and intricate ecosystem with a deeply embedded symbiotic relationship with their hosts. As more detailed information on gut microbiota complexity and functional diversity accumulates, we are learning more about how diet-microbiota interactions can influence the immune system within and outside the gut and host health in general. Heat shock proteins are a set of highly conserved proteins that are present in all types of cells, from microbes to mammals. These proteins carry out crucial intracellular housekeeping functions and unexpected extracellular immuno-regulatory features in order to maintain the mucosal barrier integrity and gut homeostasis. It is becoming evident that the enteric microbiota is one of the major determinants of heat shock protein production in intestinal epithelial cells. This review will focus on the interactions between diet, gut microbiota and their role for regulating heat shock protein production and, furthermore, how these interactions influence the immune system and the integrity of the mucosal barrier.
Keywords
heat shock protein; gut homeostasis; microbiota; tight junction protein; Lactobacillus spp.; butyrate-producing bacteria; dietary fiber
Published in
Pathogens
2014, volume: 3, number: 1, pages: 187-210
SLU Authors
Dicksved, Johan
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
Lundh, Torbjörn
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
Lindberg, Jan Erik
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
UKÄ Subject classification
Microbiology
Biochemistry and Molecular Biology
Cell Biology
Publication identifier
- DOI: https://doi.org/10.3390/pathogens3010187
Permanent link to this page (URI)
https://res.slu.se/id/publ/52850