Sun, Ren
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2013Peer reviewedOpen access
Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs
Sun, Ren; Wang, Liya
Abstract
Conclusion: We have shown that several anticancer and antiviral nucleoside and nucleobase analogs are potent inhibitors of Mpn growth and that the mechanism of inhibition are most likely due to inhibition of enzymes in the nucleotide biosynthesis pathway and nucleoside transporter. Our results suggest that enzymes in Mycoplasma nucleotide biosynthesis are potential targets for future design of antibiotics against Mycoplasma infection.
Keywords
Mycoplasma pneumoniae; Growth inhibition; 6-thioguanine; Trifluorothymidine; Hypoxanthine guanine phosphoribosyl transferase; Thymidine kinase
Published in
BMC Microbiology
2013, Volume: 13, article number: 184
Publisher: BIOMED CENTRAL LTD
Wang, Liya
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
SLU Authors
Associated SLU-program
AMR: Bacteria
Sustainable Development Goals
SDG3 Ensure healthy lives and promote well-being for all at all ages
UKÄ Subject classification
Microbiology in the medical area
Publication identifier
DOI: https://doi.org/10.1186/1471-2180-13-184
Permanent link to this page (URI)
https://res.slu.se/id/publ/55281