Wang, Liya
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
A library of purine and pyrimidine nucleosides modified with carborane or metallacarborane boron clusters at different locations, consisting of new molecules as well as already described compounds, was prepared. The compounds were tested as substrates for human deoxynucleoside kinases. Some conjugates, with modification attached to N3 of thymidine via a linker containing the triazole moiety, were efficiently phosphorylated by cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2. Higher phosphorylation levels were observed with thymidine kinase 1, the phosphorylation of nucleosides modified with metallacarboranes was observed for the first time.
Nyckelord
Carborane; metallacarborane; nucleoside conjugates; nucleoside kinase; phosphorylation
Publicerad i
Nucleosides, Nucleotides and Nucleic Acids
2013, volym: 32, nummer: 10, sidor: 571-588
Utgivare: TAYLOR & FRANCIS INC
SLU författare
Eriksson, Staffan
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Läkemedelskemi
Publikationens identifierare
- DOI: https://doi.org/10.1080/15257770.2013.838259
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/55508