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Research article2005Peer reviewed

Actinonin induces apoptosis in U937 leukemia cells

Grujic M, Zavasnik-Bergant T, Pejler G, Renko M

Abstract

We have previously shown that actinonin causes inhibition of cellular proliferation in U937 leukemia cells. In this report we demonstrate that the inhibition of cell growth by actinonin occurs through the induction of apoptosis. Signs of apoptosis at high actinonin concentration included DNA fragmentation, exposure of phosphatidylserine and condensation of cell nuclei. Apoptosis caused by actinonin was inhibited by Z-VAD-FMK, a broad specificity inhibitor of caspases, implicating the caspase pathway of apoptosis. Further, apoptosis was associated with a large increase in intracellular caspase-3 and -7 activities. (c) 2004 Elsevier Ireland Ltd. All rights reserved

Published in

Cancer Letters
2005, Volume: 223, number: 2, pages: 211-218
Publisher: ELSEVIER IRELAND LTD

      SLU Authors

    • Pejler, Gunnar

      • Department of Molecular Biosciences, Swedish University of Agricultural Sciences

      • Publication identifier

      DOI: https://doi.org/10.1016/j.caclet.2004.10.048

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/5772