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Research article2010Peer reviewed

Thymidine Kinase 1 is a Potential Marker for Prognosis and Monitoring the Response to Treatment of Patients with Breast, Lung, and Esophageal Cancer and Non-Hodgkin's Lymphoma

He, Ellen; Xu, Xiao-Hong; Guan, Hong; Chen, Yan; Chen, Zhiheng; Pan, Zhu-Lin; Tang, Lili; Hu, G. Z.; Li, Yuan; Zhang, Ming; Zhou, Ji; Eriksson, Staffan; Fornander, Tommy; Skog, Sven

Abstract

Thymidine kinase 1 (TK1) is converting thymidine to thymidine monophosphate, and is related to DNA replication and cell proliferation. The use of the TK1 protein levels as a proliferation marker in malignancies is here summarized. TK1 protein in serum (STK1p) and TK1 expression in tissues were determined by a chemoluminescent dot blot assay and by immunohistochemistry staining, respectively. The expression of TK1 in tumor tissues correlated to pathological stages and clinical grades of carcinomas (ca) of esophagus, lung and in premalignancy of breast ductal ca. STK1p could monitor the out-come of tumor therapy by being correlated to remission [breast ca, non-Hodgkin's lymphoma], relapse [breast ca] and to survival [non-Hodgkin's lymphoma] of patients. In a health screening study of 12,641 persons, STK1p seemed to predict the risk of development of neoplasia related diseases at early stage.

Keywords

Thymidine kinase 1; serum; immunohistochemistry; malignancies

Published in

Nucleosides, Nucleotides and Nucleic Acids
2010, Volume: 29, number: 4-6, pages: 352-358
Publisher: TAYLOR & FRANCIS INC

    Sustainable Development Goals

    SDG3 Ensure healthy lives and promote well-being for all at all ages

    UKÄ Subject classification

    Animal and Dairy Science
    Veterinary Science

    Publication identifier

    DOI: https://doi.org/10.1080/15257771003738535

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/60164